Dietary compound ellagic acid alleviates skin wrinkle and ... Medicinally, ellagic acid is used to prevent cancer and treat viral and bacterial infections. Ellagic acid | ≥99%(HPLC) | AdooQ® Dec 09, 2021 (The Expresswire) -- The Global "Ellagic Acid Market" Research Report 2022-2026 is a professional and in-depth study on the current state of the. 2005).Previous studies have shown that ellagic acid can protect brain cells against stress, improve cognitive ability, and prevent Alzheimer's disease (Farbood et al. Sign In. Build, train, & validate predictive machine-learning models with structured datasets. Ellagic acid (5-100 μM) shows inhibitory activities against Karpas299 . 476-66-4 - AFSDNFLWKVMVRB-UHFFFAOYSA-N - Ellagic acid [INN:DCF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. See how Contraindications & Blackbox Warnings The free polyphenol extract showed a higher inhibitory effect on α . It is possible that the increase in caffeic acid after intestinal digestion of Natal plums and Marula . Nutriceutical with anticancer and antioxidation props. Raspberry anthocyanins, punicalagin and ellagic acid, in presence of 0.5 g of glucose, were added to fecal suspensions. EA contains four hydroxyl groups and two lactone groups. Ellagic acid and its esters (-OCOC n H 2n+1) were examined in terms of phase transition, electronic structure, dielectric constant, and molecular assembly.The alternating layer arrangement of the one-dimensional π-stack and hydrophobic alkyl chains were observed in ellagic acid esters, and the in-plane amorphous glass state was observed at an optically isotropic assembly. When heated to decomposition it emits acrid smoke and irritating vapors. Ellagic acid is a naturally occurring substance. Ellagic acid (EA) and some derivatives have been reported to inhibit cancer cell proliferation, induce cell cycle arrest, and modulate some important cellular processes related to cancer. The photoreaction of the antioxidant ellagic acid (EA) elicits a drastic coloration in solution from colorless to yellow in aerated tetrahydrofuran, which appears as a new absorption band at 405 nm.Analysis of the X-ray crystal structure suggests that the photo-oxidation product of EA is a multiple cleavage π-structure (Ox-EA) that results from the interaction of EA with singlet oxygen . 44.3 ). Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite. Comparing the crystallographic binding modes of both ellagic acid and DBC, an X-ray structure-driven merging approach was taken to design novel CK2 inhibitors with improved target affinity. insoluble ellagic acid and gallic acid (as methyl gallate) from biomass substrates. Structure of Ellagic Acid {2,3,7,8-tetrahydroxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione}. Known as "a gift of the Dreamtime", it has been a traditional food and medicine for Aboriginal Australians over 60,000 years and is known to be the secret behind the sustenance of the world's longest living culture. Nutriceutical with anticancer and antioxidation props. Conclusion: The results indicate that ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum. Chemically it is 2,3,7,8-tetrahydroxy [1]benzopyranol [5,4,3-cde]benzopyran-5,10-dione ( Masamune et al., 2005) ( Fig. Properties Articles 130 Spectrum Names Ellagic acid Biological Activity Chemical & Physical Properties MSDS Ellagic acid MSDS (Chinese) Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : DJ2620000 It also has anti-proliferative and upregulated tumor suppressor genes and apoptotic genes in cancer cells . Ellagic acid (EA) is a naturally occurring poly-phenolic compound found in many fruits, such as pomegranates, persimmons, and raspberries. Ellagic acid has been found to inhibit the promotion and progression of cancer, by keeping the cancer cells from dividing and multiplying. Ellagic acid is a dilactone of hexahydroxydiphenic acid, that found in numerous fruits and vegetables. Ellagitannins belong to the class of hydrolysable tannins, they are esters of hexahydroxydiphenoic acid and monosaccharide (most commonly glucose). Whiskey tannins A and B were . Ellagic acid is bioavailable in humans where it is thought to function as an antioxidant. Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. Blank fecal suspensions without the addition of substrate were incubated simultaneously. Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. Abstract. Ellagic acid is the dilactone of hexahydroxydiphenic acid. They are produced in the human gut , and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins -containing food such as pomegranate , [2] strawberries , red . ELA is usually inserted into drug delivery Natural Pomegranate Extract, 365 Capsules, 3 Month Supply, No Magnesium or Rice Filler, 40% Ellagic Acid, Antioxidant-Rich, Made in USA, Gluten-Free, Pure Pomegranate Extract with No Additives. Last modification occurred on 12/4/2014 9:14:35 AM. Ellagic acid, a dimeric derivative of gallic acid, is generated by the hydrolysis of the ellagitannins. Ellagic acid and its esters (-OCOC n H 2n+1) were examined in terms of phase transition, electronic structure, dielectric constant, and molecular assembly.The alternating layer arrangement of the one-dimensional π-stack and hydrophobic alkyl chains were observed in ellagic acid esters, and the in-plane amorphous glass state was observed at an optically isotropic assembly. A urolithin moiety is proposed as a possible bridging scaffold between the two known CK2 inhibitors, ellagic acid and DBC. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds . The current research demonstrated the effect of ellagic acid (EA) on DEHP-induced testicular injury in mice. The present project was designed to explore the hepatoprotective effect of ellagic acid against alcohol-induced liver disease (ALD) and the correlation among alcohol, oxidative stress, inflammation, and gut microbiota. In turn, ellagic acid can be absorbed in the stomach. Ellagic acid is insoluble in water, so it has low bioavailability . Products are for laboratory research use only. Research on ellagic acid's effect on cancer first appeared in the 1970s and 1980s, but all the studies have been conducted on cell cultures or laboratory animals, according to the American Cancer Society. Ellagic acid (ELA) is an organic hetero‐tetra‐cyclic com-pound with planar phenolic lactone properties. Ellagic acid is a potent CK2 inhibitor, with an IC 50 of 40 nM and a K i of 20 nM. Ellagic acid is a naturally existing polyphenol widely found in fruits and vegetables. 1.0 2010-04-08 22:10:15 UTC 2019-11-26 03:07:07 UTC FDB012575 Ellagic acid Widely distributed in higher plants especies dicotyledons. $28. The highest levels of ellagic acid are found in . In laboratory studies, ellagic acid showed antiviral, antibacterial and antioxidant and cancer-preventive properties. 30 minutes prior and/or after (24, 47, and/or 71 h) the acid intratracheal instillation into the left lung (see Methods). Ellagic acid is the dilactone of hexahydroxydiphenic acid. Ellagic acid is a naturally occurring substance. . How does it work? Ellagic acid is a phenolic compound and also, dilactone dimer form of gallic acid. 365 Count (Pack of 1) 4.6 out of 5 stars. - 4,4 ', 5.5', 6,6'-hexahydroxydiphenic-2,6,2 ', 6'-dilactone. Ellagic acid Safety Profile. Ellagic acid hydrate | C14H8O9 | CID 16212384 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . We present a study on the binding of gallic acid and its dimer ellagic acid to glycogen phosphorylase (GP). Thirty-five healthy adult male mice were randomly divided to five groups; normal saline receiving group, DEHP (2 g/kg/day, dissolved in corn . mzCloud ‒ Free Online Mass Spectrometry Database The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, cherries, and walnuts. 5.3 The interaction between ellagic acid and graphene oxide in the ellagic acid-graphene oxide nanocomposite. Ellagic acid is a Polyphenol compound found in numerous fruits and vegetables, including, raspberries; Ellagic acid is a polyphenol antioxidant found in numerous . Meanwhile, the structure-based interaction between ellagic acid and VEGFR-2 was found to be stable conformation Phthalates such as di (2-ethylhexyl) phthalate (DEHP) are well known exogenous substances, disrupting reproductive system function and structure. The ELA is a planar phenolic lactone with two deprotonated hydroxyl groups at position eight and/or 8̀ at pH larger than 5.6 (Figure 3a) . Chemical structure of urolithin A. Urolithins are microflora human metabolites of dietary ellagic acid derivatives [1] such as ellagitannins . 1.0 2010-04-08 22:10:15 UTC 2019-11-26 03:07:07 UTC FDB012575 Ellagic acid Widely distributed in higher plants especies dicotyledons. Analysis of the X-ray crystal structure suggests that the photo-oxidation product of EA is a multiple cleavage π-structure (Ox-EA) that . Plants produce ellagic acid from hydrolysis of tannins such as ellagitannin and geraniin.Ellagic acid has antiproliferative and antioxidant properties in a number of in vitro and small-animal models. Different f rom tannic acid and the intermediates with flexible molecular structure, ellagic acid has planar structure, which was Chemical structure of ellagic acid The presence of four hydroxyl groups in its chemical structure are responsible for its antioxidant properties. Ellagic acid was first discovered by chemist Henri Braconnot in 1831. 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